S100A8人源MRP8基因表达质粒慢病毒质粒干扰敲除载体NM_002964.3 BioVector NTCC质粒载体菌种细胞蛋白抗体基因保藏中心
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S100A8人源MRP8基因表达质粒慢病毒质粒干扰敲除载体NM_002964.3
种属Human NCBI 参考序列号NM_002964.3 参考序列ORF长度282 bp 序列描述Identical with the Gene Bank Ref. ID sequence (Nucleotide may contain silent mutation without changing amino acid sequence) 描述Full length Clone DNA of Homo sapiens S100 calcium binding protein A8. S100A8 Background Information S1A8 is a member of the S1 protein family containing 2EF-hand calcium-binding motifs. S1 proteins are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. Altered expression of S1A8 protein is associated with various diseases and cancers. S1A8 may have an immunoregulatory role by contributing to the regulation of fetal-maternal interactions. It may play a protective role and its absence may allow infiltration by maternal cells, a process eventually manifesting as resorption. The heterodimeric S1 protein complex S1A8/A9 which has been shown to be involved in inflammatory and neoplastic disorders. The complex can induce cell proliferation, or apoptosis, inflammation, collagen synthesis, and cell migration. S1A8/A9 has emerged as important pro-inflammatory mediator in acute and chronic inflammation. More recently, increased S1A8 and S1A9 levels were also detected in various human cancers, presenting abundant expression in neoplastic tumor cells as well as infiltrating immune cells. On the one hand, S1A8/A9 is a powerful apoptotic agent produced by immune cells, making it a very fascinating tool in the battle against cancer. It spears the risk to induce auto-immune response and may serve as a lead compound for cancer-selective therapeutics. In contrast, S1A8/A9 expression in cancer cells has also been associated with tumor development, cancer invasion or metastasis. Altogether, its expression and potential cytokine-like function in inflammation and in cancer suggests that S1A8/A9 may play a key role in inflammation-associated cancer.Full Name S100 calcium binding protein A8 Research Areas Neuroscience>>Neurotransmission>>Calcium Signaling>>Calcium Binding Proteins Cancer>>Signal Transduction>>Neurotransmitter Receptors, Transporters, and Ion Channels>>Calcium-binding Proteins and Related Molecules Cancer>>Cancer Biomarker Cancer>>Cell Cycle>>Cell differentiation Immunology>>Innate Immunity>>Granulocyte Markers Immunology>>Inflammation / Inflammatory Mediator>>Inflammatory Mediators Neuroscience>>Cell Type Marker in Neurodevelopment>>Glial Cell Markers>>Microglia marker Immunology>>Innate Immunity>>Monocytes/Macrophages>>Monocyte Markers Cancer>>Oncoprotein & suppressor & biomarker>>Drug resistance>>MRP-related protein Immunology>>Inflammation / Inflammatory Mediator>>Cells Involved in Inflammation>>Myeloid-derived Suppressor Cells (MDSC) Neuroscience>>Neurotransmission>>Calcium Signaling>>Calcium Binding Protein>>S100 Protein References Passey RJ, et al. (1999) S100A8: emerging functions and regulation. J Leukoc Biol. 66(4): 549-56. |
BioVector NTCC质粒载体菌种细胞蛋白抗体基因保藏中心保存有此基因带有GFP荧光标签、myc、Flag、HA、His等标签和不带标签的过表达质粒，慢病毒质粒和慢病毒荧光标签质粒，以及此基因的shRNA干扰质粒等。
HA表达质粒示例：
Map
HA 标签信息
人类流感血凝素（HA）是人类病毒感染所需的表面糖蛋白。HA 标签来源于 HA 分子的 98-106 位氨基酸，已被广泛用作表达载体中的通用表位标签。许多重组蛋白质可以表达 HA 标签，它不会干扰重组蛋白质的生物活性或生物分布。HA 标签有利于目的蛋白的检测、分离和纯化。
HA 标签序列：5'TAC CCA TACGAT GTT CCA GAT TAC GCT 3' 或 5'TAT CCA TAT GAT GTT CCA GAT TAT GCT 3'; 氨基酸序列：YPYDVPDYA
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