首页 » pcDNA3.1-PVT1 plasmid-BioVector NTCC质粒载体菌种细胞基因保藏中心

pcDNA3.1-PVT1 plasmid-BioVector NTCC质粒载体菌种细胞基因保藏中心

  • 价  格:¥27930
  • 货  号:pcDNA3.1-PVT1
  • 产  地:北京
点击询问我要采购
 竭诚为您服务!
BioVector NTCC典型培养物保藏中心
联系人:Dr.Xu, Biovector NTCC Inc.

电话:400-800-2947 工作QQ:1843439339 (微信同号)

邮件:Biovector@163.com

手机:18901268599

地址:北京

已注册
 

pcDNA3.1-PVT1 plasmid


Backbone:

pcDNA3.1


Sequence of PVT1:

Homo sapiens Pvt1 oncogene (non-protein coding) (PVT1), long non-coding RNA

NCBI Reference Sequence: NR_003367.3

FASTA  Graphics

Go to:
LOCUS       NR_003367               1957 bp    RNA     linear   PRI 08-OCT-2016
DEFINITION  Homo sapiens Pvt1 oncogene (non-protein coding) (PVT1), long
            non-coding RNA.
ACCESSION   NR_003367 XM_001129539 XM_928984
VERSION     NR_003367.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1957)
  AUTHORS   Cui M, You L, Ren X, Zhao W, Liao Q and Zhao Y.
  TITLE     Long non-coding RNA PVT1 and cancer
  JOURNAL   Biochem. Biophys. Res. Commun. 471 (1), 10-14 (2016)
   PUBMED   26850852
  REMARK    GeneRIF: Studies on the association between PVT1 and cancer have
            shown that PVT1 is a potential oncogene in a variety of cancer
            types. [review]
            Review article
REFERENCE   2  (bases 1 to 1957)
  AUTHORS   Zhuang C, Li J, Liu Y, Chen M, Yuan J, Fu X, Zhan Y, Liu L, Lin J,
            Zhou Q, Xu W, Zhao G, Cai Z and Huang W.
  TITLE     Tetracycline-inducible shRNA targeting long non-coding RNA PVT1
            inhibits cell growth and induces apoptosis in bladder cancer cells
  JOURNAL   Oncotarget 6 (38), 41194-41203 (2015)
   PUBMED   26517688
  REMARK    GeneRIF: Data show that long non-coding RNA PVT1 was upregulated in
            bladder cancer tissues and cell lines.
REFERENCE   3  (bases 1 to 1957)
  AUTHORS   Zeng C, Yu X, Lai J, Yang L, Chen S and Li Y.
  TITLE     Overexpression of the long non-coding RNA PVT1 is correlated with
            leukemic cell proliferation in acute promyelocytic leukemia
  JOURNAL   J Hematol Oncol 8, 126 (2015)
   PUBMED   26545364
  REMARK    GeneRIF: Findings sugggest that the long non-coding RNA (lncRNA)
            PVT1 may play an important role in the proliferation of acute
            promyelocytic leukemia (APL) cells and may be useful for future
            therapeutic management.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1957)
  AUTHORS   Tseng YY, Moriarity BS, Gong W, Akiyama R, Tiwari A, Kawakami H,
            Ronning P, Reuland B, Guenther K, Beadnell TC, Essig J, Otto GM,
            O'Sullivan MG, Largaespada DA, Schwertfeger KL, Marahrens Y,
            Kawakami Y and Bagchi A.
  TITLE     PVT1 dependence in cancer with MYC copy-number increase
  JOURNAL   Nature 512 (7512), 82-86 (2014)
   PUBMED   25043044
  REMARK    GeneRIF: Gain of PVT1 long non-coding RNA expression was required
            for high MYC protein levels in 8q24-amplified human cancer cells
REFERENCE   5  (bases 1 to 1957)
  AUTHORS   Barsotti AM, Beckerman R, Laptenko O, Huppi K, Caplen NJ and Prives
            C.
  TITLE     p53-Dependent induction of PVT1 and miR-1204
  JOURNAL   J. Biol. Chem. 287 (4), 2509-2519 (2012)
   PUBMED   22110125
  REMARK    GeneRIF: p53-Dependent induction of PVT1 and miR-1204.
REFERENCE   6  (bases 1 to 1957)
  AUTHORS   Guan Y, Kuo WL, Stilwell JL, Takano H, Lapuk AV, Fridlyand J, Mao
            JH, Yu M, Miller MA, Santos JL, Kalloger SE, Carlson JW, Ginzinger
            DG, Celniker SE, Mills GB, Huntsman DG and Gray JW.
  TITLE     Amplification of PVT1 contributes to the pathophysiology of ovarian
            and breast cancer
  JOURNAL   Clin. Cancer Res. 13 (19), 5745-5755 (2007)
   PUBMED   17908964
  REMARK    GeneRIF: MYC and PVT1 contribute independently to ovarian and
            breast pathogenesis when overexpressed because of genomic
            abnormalities
REFERENCE   7  (bases 1 to 1957)
  AUTHORS   Shtivelman E and Bishop JM.
  TITLE     Effects of translocations on transcription from PVT
  JOURNAL   Mol. Cell. Biol. 10 (4), 1835-1839 (1990)
   PUBMED   2181290
REFERENCE   8  (bases 1 to 1957)
  AUTHORS   Shtivelman E, Henglein B, Groitl P, Lipp M and Bishop JM.
  TITLE     Identification of a human transcription unit affected by the
            variant chromosomal translocations 2;8 and 8;22 of Burkitt lymphoma
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 86 (9), 3257-3260 (1989)
   PUBMED   2470097
REFERENCE   9  (bases 1 to 1957)
  AUTHORS   Shtivelman E and Bishop JM.
  TITLE     The PVT gene frequently amplifies with MYC in tumor cells
  JOURNAL   Mol. Cell. Biol. 9 (3), 1148-1154 (1989)
   PUBMED   2725491
REFERENCE   10 (bases 1 to 1957)
  AUTHORS   Graham,M. and Adams,J.M.
  TITLE     Chromosome 8 breakpoint far 3' of the c-myc oncogene in a Burkitt's
            lymphoma 2;8 variant translocation is equivalent to the murine
            pvt-1 locus
  JOURNAL   EMBO J. 5 (11), 2845-2851 (1986)
   PUBMED   3024964COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM821521.1, BX280136.1,
            BC041065.1 and AC026248.7.
            On Sep 22, 2015 this sequence version replaced gi:389886559.
            
            Summary: This gene represents a long non-coding RNA locus that has
            been identified as a candidate oncogene. Increased copy number and
            overexpression of this gene are associated with many types of
            cancers including breast and ovarian cancers, acute myeloid
            leukemia and Hodgkin lymphoma. Allelic variants of this gene are
            also associated with end-stage renal disease attributed to type 1
            diabetes. Consistent with its association with various types of
            cancer, transcription of this gene is regulated by the tumor
            suppressor p53 through a canonical p53-binding site, and it has
            been implicated in regulating levels of the proto-oncogene MYC to
            promote tumorigenesis. [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed/partial sample support SAMEA1965299,
                              SAMEA1966682 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: PMID: 17908964
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                BM821521.1         1-21
            22-514              BX280136.1         1-493
            515-1384            BC041065.1         274-1143
            1385-1385           AC026248.7         78446-78446
            1386-1957           BC041065.1         1145-1716
FEATURES             Location/Qualifiers
     source          1..1957                     /organism="Homo sapiens"                     /mol_type="transcribed RNA"                     /db_xref="taxon:9606"                     /chromosome="8"                     /map="8q24.21"gene            1..1957                     /gene="PVT1"                     /gene_synonym="LINC00079; MYC; NCRNA00079;                     onco-lncRNA-100"                     /note="Pvt1 oncogene (non-protein coding)"                     /db_xref="GeneID:5820"                     /db_xref="HGNC:HGNC:9709"                     /db_xref="MIM:165140"ncRNA           1..1957                     /ncRNA_class="lncRNA"                     /gene="PVT1"                     /gene_synonym="LINC00079; MYC; NCRNA00079;                     onco-lncRNA-100"                     /product="Pvt1 oncogene (non-protein coding)"                     /db_xref="GeneID:5820"                     /db_xref="HGNC:HGNC:9709"                     /db_xref="MIM:165140"exon            1..202                     /gene="PVT1"                     /gene_synonym="LINC00079; MYC; NCRNA00079;                     onco-lncRNA-100"                     /inference="alignment:Splign:2.0.8"exon            203..612                     /gene="PVT1"                     /gene_synonym="LINC00079; MYC; NCRNA00079;                     onco-lncRNA-100"                     /inference="alignment:Splign:2.0.8"exon            613..781                     /gene="PVT1"                     /gene_synonym="LINC00079; MYC; NCRNA00079;                     onco-lncRNA-100"                     /inference="alignment:Splign:2.0.8"exon            782..1082                     /gene="PVT1"                     /gene_synonym="LINC00079; MYC; NCRNA00079;                     onco-lncRNA-100"                     /inference="alignment:Splign:2.0.8"exon            1083..1212                     /gene="PVT1"                     /gene_synonym="LINC00079; MYC; NCRNA00079;                     onco-lncRNA-100"                     /inference="alignment:Splign:2.0.8"exon            1213..1325                     /gene="PVT1"                     /gene_synonym="LINC00079; MYC; NCRNA00079;                     onco-lncRNA-100"                     /inference="alignment:Splign:2.0.8"exon            1326..1462                     /gene="PVT1"                     /gene_synonym="LINC00079; MYC; NCRNA00079;                     onco-lncRNA-100"                     /inference="alignment:Splign:2.0.8"exon            1463..1666                     /gene="PVT1"                     /gene_synonym="LINC00079; MYC; NCRNA00079;                     onco-lncRNA-100"                     /inference="alignment:Splign:2.0.8"exon            1667..1940                     /gene="PVT1"                     /gene_synonym="LINC00079; MYC; NCRNA00079;                     onco-lncRNA-100"                     /inference="alignment:Splign:2.0.8"regulatory      1921..1926                     /regulatory_class="polyA_signal_sequence"                     /gene="PVT1"                     /gene_synonym="LINC00079; MYC; NCRNA00079;                     onco-lncRNA-100"polyA_site      1940                     /gene="PVT1"                     /gene_synonym="LINC00079; MYC; NCRNA00079;                     onco-lncRNA-100"ORIGIN      
        1 ctccgggcag agcgcgtgtg gcggccgagc acatgggccc gcgggccggg cgggctcggg
       61 gcggccggga cgaggagggg cgacgacgag ctgcgagcaa agatgtgccc cgggaccccc
      121 ggcaccttcc agtggatttc cttgcggaaa ggatgttggc ggtccctgtg acctgtggag
      181 acacggccag atctgccctc cagcctgatc ttttggccag aaggagatta aaaagatgcc
      241 cctcaagatg gctgtgcctg tcagctgcat ggagcttcgt tcaagtattt tctgagcctg
      301 atggatttac agtgatcttc agtggtctgg ggaataacgc tggtggaacc atgcactgga
      361 atgacacacg cccggcacat ttcaggatac taaaagtggt tttaagggag gctgtggctg
      421 aatgcctcat ggattcttac agcttggatg tccatggggg acgaaggact gcagctggct
      481 gagagggttg agatctctgt ttacttagat ctctgccaac ttcctttggg tctccctatg
      541 gaatgtaaga ccccgactct tcctggtgaa gcatctgatg cacgttccat ccggcgctca
      601 gctgggcttg agctgaccat actccctgga gccttctccc gaggtgcgcg ggtgaccttg
      661 gcacatacag ccatcatgat ggtactttaa gtggaggctg aatcatctcc cctttgagct
      721 gcttggcacg tggctccctt ggtgttcccc ttttactgcc aggacactga gatttggaga
      781 gagtctcact ctgtggtcca ggctgaagta cagtggcatg atcccaggtc actgcaaccc
      841 ccacctcccg ggttcaagtg atcctcctgc ctcagcctcc cgagtagctg gtattacagg
      901 cgtgtgccac aaagcctggc taagttttgt atttttagta gagacggggt ttcaccatgt
      961 tggccaggtt ggtctcgaac tcctgacctc aagtgatcca ctcactttgg cctttcaacg
     1021 tgctgggatt acaggcgaga gtcaccgcac ccggacgact ctgacatttt tgaagagtcc
     1081 agaatcctgt tacacctggg atttaggcac tttcaatctg aaaaaataca tatcctttca
     1141 gcactctgga cggacttgag aactgtcctt acgtgaccta aagctggagt attttgagat
     1201 tggagaatta agagccagtc ttggtgctct gtgttcacct ggttcatctg aggagctgca
     1261 tctaccctgc ccatgccata gatcctgccc tgtttgcttc tcctgttgct gctagtggac
     1321 atgagaagga cagaataacg ggctcccaga ttcacaagcc ccaccaagag gatcacccca
     1381 ggaacgcttg gaggctgagg agttcactga ggctactgca tcttgagact caggatgaag
     1441 acccagcttg gggctgtcaa agaggcctga agaggcagaa caccccagag gagcctgggg
     1501 ccaccaccca gcatcactgt gggaaaacgg cagcaggaaa tgtcctctcg cctgcgtgct
     1561 ccacctcggt ccacgccttc cctccttctg gaagccttgc ctgaccactg gcctgcccct
     1621 tctatgggaa tcactactga ccttgcagct tattatagac ttatatgttt tttgcatgtc
     1681 tgacacccat gactccacct ggaccttatg gctccaccca gaagcaattc agcccaacag
     1741 gaggacagct tcaacccatt acgatttcat ctctgcccca accactcagc agcaagcacc
     1801 tgttacctgt ccacccccac cccttccccc aaactgcctt tgaaaaatcc ctaacctatg
     1861 agctttgaat aagatgagta cgaacttcat cgcccacgtg gcgtggccgg cctcgtgtct
     1921 attaaattct ttttctacta aaaaaaaaaa aaaaaaa
//


您正在向 biovector.net  发送关于产品 pcDNA3.1-PVT1 plasmid-BioVector NTCC质粒载体菌种细胞基因保藏中心 的询问

点击“立即发送”后,我们将在1个工作日内与您取得联系。