pcDNA3.1-PVT1 plasmid-BioVector NTCC质粒载体菌种细胞基因保藏中心
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pcDNA3.1-PVT1 plasmid
Backbone:
pcDNA3.1
Sequence of PVT1:
Homo sapiens Pvt1 oncogene (non-protein coding) (PVT1), long non-coding RNA
NCBI Reference Sequence: NR_003367.3
FASTA Graphics
LOCUS NR_003367 1957 bp RNA linear PRI 08-OCT-2016 DEFINITION Homo sapiens Pvt1 oncogene (non-protein coding) (PVT1), long non-coding RNA. ACCESSION NR_003367 XM_001129539 XM_928984 VERSION NR_003367.3 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1957) AUTHORS Cui M, You L, Ren X, Zhao W, Liao Q and Zhao Y. TITLE Long non-coding RNA PVT1 and cancer JOURNAL Biochem. Biophys. Res. Commun. 471 (1), 10-14 (2016) PUBMED 26850852 REMARK GeneRIF: Studies on the association between PVT1 and cancer have shown that PVT1 is a potential oncogene in a variety of cancer types. [review] Review article REFERENCE 2 (bases 1 to 1957) AUTHORS Zhuang C, Li J, Liu Y, Chen M, Yuan J, Fu X, Zhan Y, Liu L, Lin J, Zhou Q, Xu W, Zhao G, Cai Z and Huang W. TITLE Tetracycline-inducible shRNA targeting long non-coding RNA PVT1 inhibits cell growth and induces apoptosis in bladder cancer cells JOURNAL Oncotarget 6 (38), 41194-41203 (2015) PUBMED 26517688 REMARK GeneRIF: Data show that long non-coding RNA PVT1 was upregulated in bladder cancer tissues and cell lines. REFERENCE 3 (bases 1 to 1957) AUTHORS Zeng C, Yu X, Lai J, Yang L, Chen S and Li Y. TITLE Overexpression of the long non-coding RNA PVT1 is correlated with leukemic cell proliferation in acute promyelocytic leukemia JOURNAL J Hematol Oncol 8, 126 (2015) PUBMED 26545364 REMARK GeneRIF: Findings sugggest that the long non-coding RNA (lncRNA) PVT1 may play an important role in the proliferation of acute promyelocytic leukemia (APL) cells and may be useful for future therapeutic management. Publication Status: Online-Only REFERENCE 4 (bases 1 to 1957) AUTHORS Tseng YY, Moriarity BS, Gong W, Akiyama R, Tiwari A, Kawakami H, Ronning P, Reuland B, Guenther K, Beadnell TC, Essig J, Otto GM, O'Sullivan MG, Largaespada DA, Schwertfeger KL, Marahrens Y, Kawakami Y and Bagchi A. TITLE PVT1 dependence in cancer with MYC copy-number increase JOURNAL Nature 512 (7512), 82-86 (2014) PUBMED 25043044 REMARK GeneRIF: Gain of PVT1 long non-coding RNA expression was required for high MYC protein levels in 8q24-amplified human cancer cells REFERENCE 5 (bases 1 to 1957) AUTHORS Barsotti AM, Beckerman R, Laptenko O, Huppi K, Caplen NJ and Prives C. TITLE p53-Dependent induction of PVT1 and miR-1204 JOURNAL J. Biol. Chem. 287 (4), 2509-2519 (2012) PUBMED 22110125 REMARK GeneRIF: p53-Dependent induction of PVT1 and miR-1204. REFERENCE 6 (bases 1 to 1957) AUTHORS Guan Y, Kuo WL, Stilwell JL, Takano H, Lapuk AV, Fridlyand J, Mao JH, Yu M, Miller MA, Santos JL, Kalloger SE, Carlson JW, Ginzinger DG, Celniker SE, Mills GB, Huntsman DG and Gray JW. TITLE Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer JOURNAL Clin. Cancer Res. 13 (19), 5745-5755 (2007) PUBMED 17908964 REMARK GeneRIF: MYC and PVT1 contribute independently to ovarian and breast pathogenesis when overexpressed because of genomic abnormalities REFERENCE 7 (bases 1 to 1957) AUTHORS Shtivelman E and Bishop JM. TITLE Effects of translocations on transcription from PVT JOURNAL Mol. Cell. Biol. 10 (4), 1835-1839 (1990) PUBMED 2181290 REFERENCE 8 (bases 1 to 1957) AUTHORS Shtivelman E, Henglein B, Groitl P, Lipp M and Bishop JM. TITLE Identification of a human transcription unit affected by the variant chromosomal translocations 2;8 and 8;22 of Burkitt lymphoma JOURNAL Proc. Natl. Acad. Sci. U.S.A. 86 (9), 3257-3260 (1989) PUBMED 2470097 REFERENCE 9 (bases 1 to 1957) AUTHORS Shtivelman E and Bishop JM. TITLE The PVT gene frequently amplifies with MYC in tumor cells JOURNAL Mol. Cell. Biol. 9 (3), 1148-1154 (1989) PUBMED 2725491 REFERENCE 10 (bases 1 to 1957) AUTHORS Graham,M. and Adams,J.M. TITLE Chromosome 8 breakpoint far 3' of the c-myc oncogene in a Burkitt's lymphoma 2;8 variant translocation is equivalent to the murine pvt-1 locus JOURNAL EMBO J. 5 (11), 2845-2851 (1986) PUBMED 3024964COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM821521.1, BX280136.1, BC041065.1 and AC026248.7. On Sep 22, 2015 this sequence version replaced gi:389886559. Summary: This gene represents a long non-coding RNA locus that has been identified as a candidate oncogene. Increased copy number and overexpression of this gene are associated with many types of cancers including breast and ovarian cancers, acute myeloid leukemia and Hodgkin lymphoma. Allelic variants of this gene are also associated with end-stage renal disease attributed to type 1 diabetes. Consistent with its association with various types of cancer, transcription of this gene is regulated by the tumor suppressor p53 through a canonical p53-binding site, and it has been implicated in regulating levels of the proto-oncogene MYC to promote tumorigenesis. [provided by RefSeq, Sep 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: PMID: 17908964 ##RefSeq-Attributes-END## COMPLETENESS: full length. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-21 BM821521.1 1-21 22-514 BX280136.1 1-493 515-1384 BC041065.1 274-1143 1385-1385 AC026248.7 78446-78446 1386-1957 BC041065.1 1145-1716 FEATURES Location/Qualifiers source 1..1957 /organism="Homo sapiens" /mol_type="transcribed RNA" /db_xref="taxon:9606" /chromosome="8" /map="8q24.21"gene 1..1957 /gene="PVT1" /gene_synonym="LINC00079; MYC; NCRNA00079; onco-lncRNA-100" /note="Pvt1 oncogene (non-protein coding)" /db_xref="GeneID:5820" /db_xref="HGNC:HGNC:9709" /db_xref="MIM:165140"ncRNA 1..1957 /ncRNA_class="lncRNA" /gene="PVT1" /gene_synonym="LINC00079; MYC; NCRNA00079; onco-lncRNA-100" /product="Pvt1 oncogene (non-protein coding)" /db_xref="GeneID:5820" /db_xref="HGNC:HGNC:9709" /db_xref="MIM:165140"exon 1..202 /gene="PVT1" /gene_synonym="LINC00079; MYC; NCRNA00079; onco-lncRNA-100" /inference="alignment:Splign:2.0.8"exon 203..612 /gene="PVT1" /gene_synonym="LINC00079; MYC; NCRNA00079; onco-lncRNA-100" /inference="alignment:Splign:2.0.8"exon 613..781 /gene="PVT1" /gene_synonym="LINC00079; MYC; NCRNA00079; onco-lncRNA-100" /inference="alignment:Splign:2.0.8"exon 782..1082 /gene="PVT1" /gene_synonym="LINC00079; MYC; NCRNA00079; onco-lncRNA-100" /inference="alignment:Splign:2.0.8"exon 1083..1212 /gene="PVT1" /gene_synonym="LINC00079; MYC; NCRNA00079; onco-lncRNA-100" /inference="alignment:Splign:2.0.8"exon 1213..1325 /gene="PVT1" /gene_synonym="LINC00079; MYC; NCRNA00079; onco-lncRNA-100" /inference="alignment:Splign:2.0.8"exon 1326..1462 /gene="PVT1" /gene_synonym="LINC00079; MYC; NCRNA00079; onco-lncRNA-100" /inference="alignment:Splign:2.0.8"exon 1463..1666 /gene="PVT1" /gene_synonym="LINC00079; MYC; NCRNA00079; onco-lncRNA-100" /inference="alignment:Splign:2.0.8"exon 1667..1940 /gene="PVT1" /gene_synonym="LINC00079; MYC; NCRNA00079; onco-lncRNA-100" /inference="alignment:Splign:2.0.8"regulatory 1921..1926 /regulatory_class="polyA_signal_sequence" /gene="PVT1" /gene_synonym="LINC00079; MYC; NCRNA00079; onco-lncRNA-100"polyA_site 1940 /gene="PVT1" /gene_synonym="LINC00079; MYC; NCRNA00079; onco-lncRNA-100"ORIGIN 1 ctccgggcag agcgcgtgtg gcggccgagc acatgggccc gcgggccggg cgggctcggg 61 gcggccggga cgaggagggg cgacgacgag ctgcgagcaa agatgtgccc cgggaccccc 121 ggcaccttcc agtggatttc cttgcggaaa ggatgttggc ggtccctgtg acctgtggag 181 acacggccag atctgccctc cagcctgatc ttttggccag aaggagatta aaaagatgcc 241 cctcaagatg gctgtgcctg tcagctgcat ggagcttcgt tcaagtattt tctgagcctg 301 atggatttac agtgatcttc agtggtctgg ggaataacgc tggtggaacc atgcactgga 361 atgacacacg cccggcacat ttcaggatac taaaagtggt tttaagggag gctgtggctg 421 aatgcctcat ggattcttac agcttggatg tccatggggg acgaaggact gcagctggct 481 gagagggttg agatctctgt ttacttagat ctctgccaac ttcctttggg tctccctatg 541 gaatgtaaga ccccgactct tcctggtgaa gcatctgatg cacgttccat ccggcgctca 601 gctgggcttg agctgaccat actccctgga gccttctccc gaggtgcgcg ggtgaccttg 661 gcacatacag ccatcatgat ggtactttaa gtggaggctg aatcatctcc cctttgagct 721 gcttggcacg tggctccctt ggtgttcccc ttttactgcc aggacactga gatttggaga 781 gagtctcact ctgtggtcca ggctgaagta cagtggcatg atcccaggtc actgcaaccc 841 ccacctcccg ggttcaagtg atcctcctgc ctcagcctcc cgagtagctg gtattacagg 901 cgtgtgccac aaagcctggc taagttttgt atttttagta gagacggggt ttcaccatgt 961 tggccaggtt ggtctcgaac tcctgacctc aagtgatcca ctcactttgg cctttcaacg 1021 tgctgggatt acaggcgaga gtcaccgcac ccggacgact ctgacatttt tgaagagtcc 1081 agaatcctgt tacacctggg atttaggcac tttcaatctg aaaaaataca tatcctttca 1141 gcactctgga cggacttgag aactgtcctt acgtgaccta aagctggagt attttgagat 1201 tggagaatta agagccagtc ttggtgctct gtgttcacct ggttcatctg aggagctgca 1261 tctaccctgc ccatgccata gatcctgccc tgtttgcttc tcctgttgct gctagtggac 1321 atgagaagga cagaataacg ggctcccaga ttcacaagcc ccaccaagag gatcacccca 1381 ggaacgcttg gaggctgagg agttcactga ggctactgca tcttgagact caggatgaag 1441 acccagcttg gggctgtcaa agaggcctga agaggcagaa caccccagag gagcctgggg 1501 ccaccaccca gcatcactgt gggaaaacgg cagcaggaaa tgtcctctcg cctgcgtgct 1561 ccacctcggt ccacgccttc cctccttctg gaagccttgc ctgaccactg gcctgcccct 1621 tctatgggaa tcactactga ccttgcagct tattatagac ttatatgttt tttgcatgtc 1681 tgacacccat gactccacct ggaccttatg gctccaccca gaagcaattc agcccaacag 1741 gaggacagct tcaacccatt acgatttcat ctctgcccca accactcagc agcaagcacc 1801 tgttacctgt ccacccccac cccttccccc aaactgcctt tgaaaaatcc ctaacctatg 1861 agctttgaat aagatgagta cgaacttcat cgcccacgtg gcgtggccgg cctcgtgtct 1921 attaaattct ttttctacta aaaaaaaaaa aaaaaaa //
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