Anti-Zaire Ebola Virus VP35 Protein, Antibody埃博拉病毒VP35蛋白抗体 BioVector NTCC质粒载体菌种细胞基因保藏中心

Anti-Zaire Ebola Virus VP35 Protein, Antibody埃博拉病毒VP35蛋白抗体 BioVector NTCC质粒载体菌种细胞基因保藏中心 Anti-Zaire Ebola Virus VP35 Protein, Antibody Cat#: BioVector591672 Antigen: Zaire ebolavirus polymerase cofactor VP35 Accession ID: AF086833.2 Ebola Mayinga, Zaire 1976 Molecular Weight: 35 kDa Isotype: IgG2a Clonality: Monoclonal Clone Name: 6C5 Reactivity: Virus Immunogen: DNA immunization followed by recombinant protein Species Immunized: Mouse Epitope: Within C-terminal portion of protein Purification Method: Protein G Affinity Buffer: 0.1M Sodium Phosphate, pH 7.4, 0.15M NaCl, 0.05% (w/v) Sodium Azide Tested Applications: WB (1:1000), IP (1:500), IF Storage: -20C Shipped: Cold packs This mouse IgG2a monoclonal antibody [6C5] was generated against DNA immunization followed by recombinant protein and is specific for the C-terminal portion of Zaire ebolavirus polymerase cofacter VP35 protein. Highlights: • Reacts with the C-terminal portion of Zaire ebolavirus polymerase cofacter VP35 protein • Suitable for Western Blot, Immunoprecipitation and Immunofluorescence applications Ebola virus (EBOV), or sometimes referred to as Zaire ebolavirus is one of the five identified Ebola virus species. Zaire ebolavirus is a virological taxon that comes from the genus, Ebolvarius, family Filoviridae and the order Mononegavirales. Ebola, often fatal has been shown to cause hemorrhagic fever in humans and other mammals including monkeys and chimpanzees. Polymerase cofactor VP35 acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. It prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3). This blockage is produced through the interaction with and inhibition of host IKBKE and TBK1. VP35 also inhibits the antiviral effect mediated by the host interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR.
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