pMuc2-Luc BioVector NTCC质粒载体菌种细胞基因保藏中心

pMuc2-Luc BioVector NTCC质粒载体菌种细胞基因保藏中心 MUC2/Luciferase Plasmid Construction and Transient Transfection Assays
Summary for MUC2 Gene
This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Downregulation of this gene has been observed in patients with Crohn disease and ulcerative colitis. [provided by RefSeq, Oct 2016]
GeneCards Summary for MUC2 Gene
MUC2 (Mucin 2, Oligomeric Mucus/Gel-Forming) is a Protein Coding gene. Diseases associated with MUC2 include Pseudomyxoma Peritonei and Signet Ring Cell Adenocarcinoma. Among its related pathways are O-linked glycosylation and HIV Life Cycle.
UniProtKB/Swiss-Prot for MUC2 Gene
MUC2_HUMAN,Q02817
Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer.
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