EHEC O157：H7 sakai BioVector NTCC质粒载体菌种细胞基因保藏中心

EHEC O157：H7 sakai BioVector NTCC质粒载体菌种细胞基因保藏中心
Escherichia coli O157:H7 is the prevalent variant of enterohemorrhagic
E. coli (EHEC) associated with hemorrhagic enteritis
and hemolytic uremic syndrome in humans in the United
States (26, 51). E. coli O157:H7 has to survive a number of
environmental stresses during transmission from cows to humans.
Surviving acid stress is critical during transmission, as
the typical human stomach pH ranges from 1.5 to 3.0 (40). E.
coli strains exhibit more acid resistance (AR) than other enteric
pathogens, and this AR is considered a virulence factor in
E. coli O157:H7, as it contributes to the low infective dose (10,
40). E. coli has four distinct AR mechanisms, the oxidative
(OXI) system, glutamate decarboxylase (GAD) system, arginine
decarboxylase (ARG) system, and lysine decarboxylase
system (18, 32), that are phenotypically distinct and provide
protection against low pH dependent on the type of acidic
environment encountered (42). In addition to the defined
mechanisms, other factors of the general stress response, including
the stress response sigma factor RpoS and the DNA
binding protein Dps, also contribute to the AR of E. coli
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