C28/I2 Human Chondrocyte Cell Line BioVector NTCC质粒载体菌种细胞基因保藏中心

C28/I2 Human Chondrocyte Cell Line BioVector NTCC质粒载体菌种细胞基因保藏中心
Description C28/I2 Human Chondrocyte Cell Line
Overview The chondrocyte is the only specialized cell type present in articular cartilage. They produce secretions to support and repair the cartilage matrix. Human chondrocytes in mature articular cartilage are post-mitotic and terminally differentiated cells. Studies on human chondrocytes have been hampered by the difficulty in obtaining sufficient numbers of primary human chondrocytes from a single joint and by variabilities among donors due to factors such as age and medical conditions.

C-28/I2 is a clonal line derived from the nonclonal T/C-28a4 cells which were immortalized via retroviral vector-mediated simian virus SV40 Large T antigen (Tag) expression..

References:
1. Goldring, M.B, Birkhead, J.R., Suen, L.F., Yamin, R., Mizuno, S., Glowacki, J., Arbiser, J.L, Apperley, J.F. (1994) Interleukin-1 beta-modulated gene expression in immortalized human chondrocytes. J. Clin. Invest 94(6): 2307-2316.
2. Claassen, H., Schicht, M., Brandt, J., Reuse, K., Schadlich, R., Goldring, M.B., Guddat, S.S., Thate, A., Paulsen, F. C-28/I2 and T/C-28a2 chondrocytes as well as human primary articular chondrocytes express hormone and insulin receptors- Useful cells in study of cartilage metabolism. Ann Anat. 193(1): 23-29.
3. Goldring, M.B. (2004) Culture of immortalized chondrocytes and their use as models of chondrocyte function. Methods Mol. Med. 100: 37-52.
Alternate Names • C-28/I2
Applications
Application C28/I2 Human Chondrocyte Cell Line is widely used as a model cell line for studying normal and pathological cartilage repair mechanisms related to chondrocyte biology and physiology.
Markers:
Amelogenin X
CSF1PO 12
D13S317 9,11
D16S539 12,13
D18S51 16,19
D21S11 27,29
D3S1358 16
D5S818 11
D7S820 8,10
D8S1179 11,13
FGA 20
Penta D 14
Penta E 7,11
TH01 9.3
TPOX 8
vWA 14


BioVector NTCC质粒载体菌种细胞蛋白抗体基因保藏中心
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【Supplier来源】BioVector NTCC Inc.
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