pcDNA3.1-TGF-β1.Human transforming growth factor, beta 1 (TGFB1) BioVector NTCC质粒载体菌种细胞基因保藏中心

pcDNA3.1-TGF-β1.Human transforming growth factor, beta 1 (TGFB1) BioVector NTCC质粒载体菌种细胞基因保藏中心
Human transforming growth factor, beta 1 (TGFB1)
RefSeq: NM_000660.3, NP_000651
RefSeq Size: 2346 RefSeq ORF: 1173
Synonyms : CED; DPD1; LAP; TGFB; TGFbeta
LocusID: 7040 Cytogenetic: 19q13.2 Domains: TGFb_propeptide, TGFB
Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.
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