pcDNA3.1-ADAMTS18过表达质粒 BioVector NTCC质粒载体菌种细胞基因保藏中心

pcDNA3.1-ADAMTS18过表达质粒 BioVector NTCC质粒载体菌种细胞基因保藏中心
RefSeq NM_199355.1, NM_199355.2, NM_199355.3, NP_955387
RefSeq Size 5510
RefSeq ORF 3666
Locus ID 170692
Cytogenetics 16q23.1
Protein Families Secreted Protein, Protease
MW 135 kDa
Gene Summary This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may regulate hemostatic balance and function as a tumor suppressor. Mutations in this gene may be associated with microcornea, myopic chorioretinal atrophy, and telecanthus (MMCAT) and cone-rod dystrophy in human patients.
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