E.coli EC958 strain大肠杆菌菌株菌种 BioVector NTCC质粒载体菌种细胞基因保藏中心

E.coli EC958 strain大肠杆菌菌株菌种 BioVector NTCC质粒载体菌种细胞基因保藏中心
E. coli EC958, which was isolated from the urine of a patient presenting with a urinary tract infection in the Northwest region of England and represents the most well characterised ST131 strain. E. coli EC958 belongs to the major subgroup of ST131 strains that produce the CTX-M-15 extended spectrum β-lactamase, are fluoroquinolone resistant and encode the fimH30 type 1 fimbrial adhesin. This subgroup includes the Indian strain NA114 and the North American strain JJ1886. A comparison of the genomes of EC958, JJ1886 and NA114 revealed that differences in the arrangement of genomic islands, prophages and other repetitive elements in the NA114 genome are not biologically relevant and are due to misassembly.
E. coli EC958 represents one of the most well characterised E. coli ST131 strains in the literature. E. coli EC958 is a phylogenetic group B2, CTX-M-15 positive, fluoroquinolone resistant, H30 E. coli ST131 strain isolated from the urine of an 8-year old girl presenting in the community in March 2005 in the United Kingdom (UK) [7]. The strain belongs to the pulse field gel electrophoresis defined UK epidemic strain A and has a O25b:H4 serotype [8]. E. coli EC958 contains multiple genes associated with the virulence of extra-intestinal E. coli, including those encoding adhesins, autotransporter proteins and siderophore receptors. E. coli EC958 expresses type 1 fimbriae and this is required for adherence to and invasion of human bladder cells, as well as colonization of the mouse bladder [7]. In mice, E. coli EC958 causes acute and chronic urinary tract infection (UTI) [9], as well as impairment of ureter contractility [10]. E. coli EC958 bladder infection follows a well-defined pathogenic pathway that involves the formation of intracellular bacterial communities (IBCs) in superficial epithelial cells and the subsequent release of rod-shaped and filamentous bacteria into the bladder lumen [9]. E. coli EC958 also causes impairment of uterine contractility [10], and is resistant to the bactericidal action of human serum [11]. The complement of genes that define the serum resistome of E. coli EC958 have been comprehensively defined
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