UM-SCC-22B cell line细胞株细胞系 BioVector NTCC质粒载体菌种细胞基因保藏中心

UM-SCC-22B cell line细胞株细胞系 BioVector NTCC质粒载体菌种细胞基因保藏中心
Cell line name UM-SCC-22B
Synonyms UM-SCC 22B; UMSCC-22B; UMSCC22B; UM-SCC22B; SCC22B; UMC-22b; UMC22b; UMC22B; UM-22B; University of Michigan-Squamous Cell Carcinoma-22B; 22B
Accession CVCL_7732
Resource Identification Initiative To cite this cell line use: UM-SCC-22B (RRID:CVCL_7732)
Comments Problematic cell line: Partially contaminated. At least one lab used a stock contaminated by T24 (CVCL_0554) (PubMed=29873307).
Part of: MD Anderson Cell Lines Project.
Doubling time: 34 +- 2 hours (PubMed=9139877).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: Genome sequenced (low read coverage).
Omics: Protein expression by reverse-phase protein arrays.
Sequence variations Homozygous for CDKN2A deletion (PubMed=31541927).
Homozygous for NOTCH1 p.Glu1679Ter (c.5035G>T) (PubMed=31541927).
TP53 p.Tyr220Cys (c.659A>G) and c.993+1G>T; splice donor mutation (PubMed=15287027; PubMed=16203773; PubMed=18006756; PubMed=18487078; PubMed=23613873; PubMed=31541927).
Disease Hypopharyngeal squamous cell carcinoma (NCIt: C4043)
Derived from metastatic site: Cervical lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_7731 ! UM-SCC-22A
Sex of cell Female
Age at sampling 59Y
Category Cancer cell line
STR profile Source(s): Millipore; PubMed=19760794; PubMed=21868764

Markers:
Amelogenin X
CSF1PO 10
D3S1358 16
D5S818 12
D7S820 8,9
D8S1179 11,13
D13S317 8,12
D16S539 9,11
D18S51 18
D21S11 28
FGA 22,24
Penta D 13
Penta E 12,18
TH01 6
TPOX 8,11
vWA 15,18

Run an STR similarity search on this cell line
Web pages http://tcpaportal.org/mclp/
Publications
PubMed=3335022
Alley M.C., Scudiero D.A., Monks A., Hursey M.L., Czerwinski M.J., Fine D.L., Abbott B.J., Mayo J.G., Shoemaker R.H., Boyd M.R.
Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.
Cancer Res. 48:589-601(1988)
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