PARP2 gene基因表达质粒敲除编辑载体 BioVector NTCC质粒载体菌种细胞基因保藏中心

PARP2 gene基因表达质粒敲除编辑载体

Human poly (ADP-ribose) polymerase 2 (PARP2)

RefSeq NM_005484.4
RefSeq Size 1904 bp
RefSeq ORF 1752 bp
Locus ID 10038
Domains PARP, PARP_reg
Protein Families Druggable Genome
Protein Pathways Base excision repair
MW 66 kDa
Gene Summary This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found.

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