Ade7 yeast mutant strain酵母突变菌株 BioVector NTCC质粒载体菌种细胞基因保藏中心

Ade7 yeast mutant strain酵母突变菌株

BioVector-YM3203 Ade7 yeast mutant strain
Introduction
Standard Name
ADE7
Strain ID
BioVector-YM3203
Feature Type
ORF , Verified

Description
Bifunctional enzyme of 'de novo' purine nucleotide pathway; contains both phosphoribosylglycinamidine synthetase/glycinamide ribotide synthetase (EC 6.3.4.13) ["Ade5"] and phosphoribosylaminoimidazole synthetase/aminoimidazole ribotide synthetase (EC 6.3.3.1) ["Ade7"] activities 1 2

Name Description
ADEnine requiring


ADE57 Location: Chromosome VII 56482..58890


Subfeatures - S288C


Feature Relative Coordinates Coordinates Coord. Version Seq. Version
CDS 1..2409 chrVII:56482..58890 2004-07-15 1996-07-31

Protein
Length (a.a.) 802
Mol. Weight (Da) 86041.7
Isoelectric Point 4.89
Median Abundance (molecules/cell) 28081 +/- 6236
Alleles: ade7-Δ

Gene Ontology
Putative phosphoribosylamine-glycine ligase and phosphoribosylformylglycinamidine cyclo-ligase likely to be involved in purine nucleobase metabolic process; localized to the cytoplasm
Molecular Function
enables phosphoribosylamine-glycine ligase activity (ISS)
enables phosphoribosylformylglycinamidine cyclo-ligase activity (ISS)

Biological Process
involved in purine nucleobase metabolic process (TAS)

Cellular Component
part of cytoplasm (HDA)

Pathways
superpathway of purine nucleotides de novo biosynthesis II
superpathway of purine biosynthesis and salvage pathways
superpathway of histidine, purine, and pyrimidine biosynthesis
de novo biosynthesis of purine nucleotides

Phenotype
Non-essential gene; null mutant displays adenine auxotrophy; in large-scale studies null mutant shows decreased competitive fitness, shortened chronological lifespan and lower innate thermotolerance

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