Human colony stimulating factor 1 receptor (CSF1R) gene基因表达质粒敲除编辑载体 BioVector NTCC质粒载体菌种细胞基因保藏中心
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Human colony stimulating factor 1 receptor (CSF1R) gene基因表达质粒敲除编辑载体
RefSeq NM_005211.3, NP_005202.2RefSeq Size 3985 bpRefSeq ORF 2919 bpLocus ID 1436UniProt ID P07333Cytogenetics 5q32Domains pkinase, TyrKc, S_TKc, ig, IGc2, IGProtein Families Druggable Genome, Protein Kinase, TransmembraneProtein Pathways Cytokine-cytokine receptor interaction, Endocytosis, Hematopoietic cell lineage, Pathways in cancerMW 107.8 kDaGene Summary The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. Expression of a splice variant from an LTR promoter has been found in Hodgkin lymphoma (HL), HL cell lines and anaplastic large cell lymphoma.
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RefSeq NM_005211.3, NP_005202.2RefSeq Size 3985 bpRefSeq ORF 2919 bpLocus ID 1436UniProt ID P07333Cytogenetics 5q32Domains pkinase, TyrKc, S_TKc, ig, IGc2, IGProtein Families Druggable Genome, Protein Kinase, TransmembraneProtein Pathways Cytokine-cytokine receptor interaction, Endocytosis, Hematopoietic cell lineage, Pathways in cancerMW 107.8 kDaGene Summary The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. Expression of a splice variant from an LTR promoter has been found in Hodgkin lymphoma (HL), HL cell lines and anaplastic large cell lymphoma.
Supplier来源:BioVector NTCC Inc.
TEL电话:400-800-2947
Website网址: http://www.biovector.net
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