CT26-OVA cell line稳转细胞株 BioVector NTCC质粒载体菌种细胞基因保藏中心

CT26-OVA cell line稳转细胞株

In colorectal cancer, Wnt/β-catenin signaling is often aberrantly activated and associated with a T-cellexcluded phenotype which is a major obstacle for many immunotherapies. However, the effects of Wnt/βcatenin inhibition on tumor immunity and immunotherapy remain to be elucidated. In syngeneic mouse
models of colorectal cancer, β-catenin/TCF inhibitor iCRT14 potently enhanced the infiltration of T and NK
cells, without influencing their proliferation or the infiltration of most myeloid populations.
Mechanistically, β-catenin inhibition upregulated while its overexpression suppressed the expression of
T/NK cell-recruiting CXCR3 chemokines CXCL9/10/11 in both mouse and human colorectal cancer cells.
Furthermore, iCRT14 treatment synergized with tumor vaccines or Treg cell ablation to achieve
a complete inhibition of tumor growth in syngeneic models of CT26-OVA and MC38-S33Y.β-cat, respectively. Taken together, our work reveals that β-catenin inhibition shifts colorectal tumor microenvironment into a T-cell-inflamed phenotype and potentiates the efficacy of other immunotherapeutic
strategies for colorectal cancer.

Supplier来源:BioVector NTCC Inc.
TEL电话:400-800-2947
Website网址: http://www.biovector.net