H1299/GFP-DDP cell line荧光稳转耐药细胞株 BioVector NTCC质粒载体菌种细胞基因保藏中心
- 价 格：¥989865
- 货 号：H1299/GFP-DDP
- 产 地：北京
- BioVector NTCC典型培养物保藏中心
- 联系人：Dr.Xu, Biovector NTCC Inc.
电话：400-800-2947 工作微信:1843439339 (QQ同号)
邮件：Biovector@163.com
手机：18901268599
地址：北京
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H1299/GFP-DDP cell line荧光稳转耐药细胞株
PCDNA3.1 vehicle and PEGFP-N1 plasmid with the green fluorescent protein (GFP) gene were transfected into the H1299 cells Cisplatin [Cis-diammine-dichloroplatinum (II), DDP] and its analogue carboplatin are the most commonly used platinum agents in the platinum-based chemotherapy of NSCLC (6,7). They are heavy metal complexes, and present their therapeutic cytotoxic properties by covalently binding to DNA to form intra- and interstrand cross-links which interfere with normal DNA replication and transcription (8,9). Without efficient DNA repair, the platinum-induced DNA damage eventually leads to cell apoptosis (5). Although the platinum containing agents greatly increase the effectiveness of NSCLC treatment compared with other drugs, platinum-based chemotherapy has apparently reached a therapeutic plateau with limited response to treatment as well as little improvement of survival for patients (10,11), due to the tumors rapidly developing acquired drug resistance which has not yet been overcome (12). Many published reports suggest that the emergence of platinum resistance, not only intrinsic, but also acquired primarily attribute to the nucleotide excision repair (NER) system
Supplier来源:BioVector NTCC Inc.
TEL电话:400-800-2947
Website网址: http://www.biovector.net
PCDNA3.1 vehicle and PEGFP-N1 plasmid with the green fluorescent protein (GFP) gene were transfected into the H1299 cells Cisplatin [Cis-diammine-dichloroplatinum (II), DDP] and its analogue carboplatin are the most commonly used platinum agents in the platinum-based chemotherapy of NSCLC (6,7). They are heavy metal complexes, and present their therapeutic cytotoxic properties by covalently binding to DNA to form intra- and interstrand cross-links which interfere with normal DNA replication and transcription (8,9). Without efficient DNA repair, the platinum-induced DNA damage eventually leads to cell apoptosis (5). Although the platinum containing agents greatly increase the effectiveness of NSCLC treatment compared with other drugs, platinum-based chemotherapy has apparently reached a therapeutic plateau with limited response to treatment as well as little improvement of survival for patients (10,11), due to the tumors rapidly developing acquired drug resistance which has not yet been overcome (12). Many published reports suggest that the emergence of platinum resistance, not only intrinsic, but also acquired primarily attribute to the nucleotide excision repair (NER) system
Supplier来源:BioVector NTCC Inc.
TEL电话:400-800-2947
Website网址: http://www.biovector.net
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