Fyn (pY528)/c-Src (pY530) Mouse, Unlabeled, Clone: 31 antibody单克隆抗体 BioVector NTCC质粒载体菌种细胞基因保藏中心
- 价 格：¥98965
- 货 号：Fyn (pY528)/c-Src (pY530) Mouse, Unlabeled, Clone: 31
- 产 地：北京
- BioVector NTCC典型培养物保藏中心
- 联系人：Dr.Xu, Biovector NTCC Inc.
电话：400-800-2947 工作微信:1843439339 (QQ同号)
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手机：18901268599
地址：北京
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Fyn (pY528)/c-Src (pY530) Mouse, Unlabeled, Clone: 31 antibody单克隆抗体
p59fyn is a member of the Src family of protein tyrosine kinases. Two isoforms of the protein have been identified, designated as FynB and Fyn T. Fyn B has been shown to be localized to the brain, whereas Fyn T associates with both B and T cells. Stimulation of the T cell antigen receptor (TcR) results in protein tyrosine phosphorylation via non-receptor tyrosine kinases. p59fyn kinase (Fyn T) associates with the TcR. Ligation of the TcR activates the protein kinase activity of p59fyn in various human T cells. Fyn interacts with the CD3-zeta chains through its N-terminal region. In turn, fyn binds other proteins through its SH2 and SH3 domains. These proteins (p82 and p116) may serve as substrates and/or mediators of fyn activity. p59fyn kinase is tyrosine phosphorylated at two sites, Tyr-417 (autophosphorylation site), and Tyr-528 (negative regulatory site).Intracellular Staining, Western BlottingSpecificationsAntigenFyn (pY528)/c-Src (pY530)ClassificationMonoclonalConcentration250μg/mLFormulationAqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.ImmunogenPhosphorylated Human Fyn (Y528) PeptideQuantity50 μgResearch DisciplineCell BiologyTarget SpeciesHuman, MouseIsotypeIgG2bApplicationsWestern BlotClone31ConjugateUnconjugatedHost SpeciesMousePurification MethodAffinity PurifiedRegulatory StatusRUOPrimary or SecondaryPrimaryContent And StorageStore undiluted at -20°C.
Supplier来源:BioVector NTCC Inc.
TEL电话:400-800-2947
Website网址: http://www.biovector.net
p59fyn is a member of the Src family of protein tyrosine kinases. Two isoforms of the protein have been identified, designated as FynB and Fyn T. Fyn B has been shown to be localized to the brain, whereas Fyn T associates with both B and T cells. Stimulation of the T cell antigen receptor (TcR) results in protein tyrosine phosphorylation via non-receptor tyrosine kinases. p59fyn kinase (Fyn T) associates with the TcR. Ligation of the TcR activates the protein kinase activity of p59fyn in various human T cells. Fyn interacts with the CD3-zeta chains through its N-terminal region. In turn, fyn binds other proteins through its SH2 and SH3 domains. These proteins (p82 and p116) may serve as substrates and/or mediators of fyn activity. p59fyn kinase is tyrosine phosphorylated at two sites, Tyr-417 (autophosphorylation site), and Tyr-528 (negative regulatory site).Intracellular Staining, Western BlottingSpecificationsAntigenFyn (pY528)/c-Src (pY530)ClassificationMonoclonalConcentration250μg/mLFormulationAqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.ImmunogenPhosphorylated Human Fyn (Y528) PeptideQuantity50 μgResearch DisciplineCell BiologyTarget SpeciesHuman, MouseIsotypeIgG2bApplicationsWestern BlotClone31ConjugateUnconjugatedHost SpeciesMousePurification MethodAffinity PurifiedRegulatory StatusRUOPrimary or SecondaryPrimaryContent And StorageStore undiluted at -20°C.
Supplier来源:BioVector NTCC Inc.
TEL电话:400-800-2947
Website网址: http://www.biovector.net
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