pcDNA3.1-Vcp基因表达质粒敲除编辑载体Human valosin containing protein (VCP) BioVector NTCC质粒载体菌种细胞基因保藏中心

pcDNA3.1-Vcp基因表达质粒敲除编辑载体Human valosin containing protein (VCP)

Human valosin containing protein (VCP)

RefSeq NM_007126.2
RefSeq Size 3859 bp
RefSeq ORF 2421 bp
Locus ID 7415
Domains cdc48_N, AAA, AAA
MW 89.3 kDa
Gene Summary This gene encodes a member of the AAA ATPase family of proteins. The encoded protein plays a role in protein degradation, intracellular membrane fusion, DNA repair and replication, regulation of the cell cycle, and activation of the NF-kappa B pathway. This protein forms a homohexameric complex that interacts with a variety of cofactors and extracts ubiquitinated proteins from lipid membranes or protein complexes. Mutations in this gene cause IBMPFD (inclusion body myopathy with paget disease of bone and frontotemporal dementia), ALS (amyotrophic lateral sclerosis) and Charcot-Marie-Tooth disease in human patients.

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