c28/i2 Human Chondrocyte Cell Line SCC043人软骨细胞株 BioVector NTCC质粒载体菌种细胞基因保藏中心

BioVector® NTCC® c28/i2 Human Chondrocyte Cell Line SCC043人软骨细胞株

C28/I2 Human Chondrocyte Cell Line is widely used as a model cell line for studying normal and pathological cartilage repair mechanisms related to chondrocyte biology and physiology.

additional Chondrocyte cell lines:
C20A4 Human Chondrocyte Cell Line (Catalogue Number NTCC®SCC041)
TC28a2 Human Chondrocyte Cell Line (Catalogue Number NTCC®SCC042)
Key Spec Table
Key Applications
CULT
Description
Catalogue NumberNTCC®-SCC043
DescriptionC28/I2 Human Chondrocyte Cell Line
OverviewThe chondrocyte is the only specialized cell type present in articular cartilage. They produce secretions to support and repair the cartilage matrix. Human chondrocytes in mature articular cartilage are post-mitotic and terminally differentiated cells. Studies on human chondrocytes have been hampered by the difficulty in obtaining sufficient numbers of primary human chondrocytes from a single joint and by variabilities among donors due to factors such as age and medical conditions.

C-28/I2 is a clonal line derived from the nonclonal T/C-28a4 cells which were immortalized via retroviral vector-mediated simian virus SV40 Large T antigen (Tag) expression..

References:
1. Goldring, M.B, Birkhead, J.R., Suen, L.F., Yamin, R., Mizuno, S., Glowacki, J., Arbiser, J.L, Apperley, J.F. (1994) Interleukin-1 beta-modulated gene expression in immortalized human chondrocytes. J. Clin. Invest 94(6): 2307-2316.
2. Claassen, H., Schicht, M., Brandt, J., Reuse, K., Schadlich, R., Goldring, M.B., Guddat, S.S., Thate, A., Paulsen, F. C-28/I2 and T/C-28a2 chondrocytes as well as human primary articular chondrocytes express hormone and insulin receptors- Useful cells in study of cartilage metabolism. Ann Anat. 193(1): 23-29.
3. Goldring, M.B. (2004) Culture of immortalized chondrocytes and their use as models of chondrocyte function. Methods Mol. Med. 100: 37-52.
Alternate Names
C-28/I2

Product Usage Statements
Quality Assurance• Each vial contains ≥ 1X106 viable cells.
• Cells are tested by PCR and are negative for HPV-16, HPV-18, Hepatitis A, B, C and HIV-1 & 2 viruses.
• Cells are negative for mycoplasma contamination.
• Each lot of cells are genotyped by STR analysis to verify the unique identity of the cell line.

Supplier来源:BioVector NTCC Inc.
Email: biovector@163.com
Website网址: http://www.biovector.net