MOLT-16 NTCC®人T细胞急性淋巴细胞白血病细胞株T-cell acute lymphoblastic leukemia (T-ALL) cell line-BioVector NTCC典型培养物保藏中心

价　　格：¥99860
货　　号：NTCC®MOLT-16
产　　地：北京

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The NTCC® MOLT-16 cell line is a human cell line used as a model for T-cell acute lymphoblastic leukemia (T-ALL), a highly aggressive type of blood cancer. It was established from the peripheral blood of a 5-year-old girl who had a relapse of T-ALL.

Key Characteristics

Acute lymphoblastic leukemia - Wikipedia

Origin: The cell line was derived in 1984 and is a sister cell line to MOLT-17.
Cell Type: It is a T-lymphoblastoid cell line, meaning it is a type of white blood cell (T-cell) that has become cancerous and has immature characteristics (lymphoblast).
Growth: The cells grow in suspension, which is typical for blood cancer cell lines.
Genetic Profile:
- It has a near-diploid karyotype, but with several complex chromosomal translocations.
- A significant genetic feature is a translocation involving chromosomes 8 and 14, specifically t(8;14)(q24;q11). This translocation brings the MYC oncogene on chromosome 8 into close proximity with the T-cell receptor alpha chain (TCR-alpha) gene on chromosome 14, leading to the overexpression of the MYC oncogene, which is a known driver of cancer.
- It expresses key T-cell markers such as CD2, CD3, CD5, CD7, and the T-cell receptor.
Drug Sensitivity: The MOLT-16 cell line has been profiled for its sensitivity to various drugs, and this data is used in drug screening projects.

Research Applications

The MOLT-16 cell line is a valuable resource for oncology research, especially in the study of pediatric T-ALL. Its main applications include:

Disease Modeling: It serves as a representative model for T-cell acute lymphoblastic leukemia, allowing researchers to study the disease's progression and unique biological properties.
Genetic and Molecular Studies: The cell line is used to investigate the role of specific genetic mutations and translocations (like the t(8;14) translocation) in the development and maintenance of T-ALL.
Drug Discovery and Screening: Due to its established genetic and drug-response profiles, it is a key tool for screening new therapeutic agents and understanding the mechanisms of drug resistance.

NTCC® MOLT-16 细胞系是一种人类细胞系，被用作**T 细胞急性淋巴细胞白血病（T-ALL）**的模型。T-ALL 是一种侵袭性极强的血液癌症。该细胞系是从一名患有 T-ALL 复发的5岁女孩的外周血中建立的。

主要特点

来源: 该细胞系于1984年建立，是 MOLT-17 细胞系的姊妹系。
细胞类型: 它是 T 淋巴母细胞样细胞系，意味着它是一种已癌变的白细胞（T 细胞），并具有未成熟的特征（淋巴母细胞）。
生长方式: 这些细胞在悬浮培养中生长，这是血癌细胞系的典型特征。
遗传学特征:
- 它具有近二倍体核型，但存在多个复杂的染色体易位。
- 一个重要的遗传特征是涉及8号和14号染色体的易位，即 t(8;14)(q24;q11)。该易位将8号染色体上的 MYC 致癌基因与14号染色体上的 T 细胞受体α链（TCR-alpha）基因紧密相连，导致 MYC 致癌基因的过表达，而 MYC 基因是已知的癌症驱动基因。
- 它表达关键的 T 细胞标记物，如 CD2、CD3、CD5、CD7 和 T 细胞受体。
药物敏感性: MOLT-16 细胞系已针对多种药物的敏感性进行了分析，这些数据被用于药物筛选项目。