SK-MEL-23 NTCC™人黑色素瘤细胞株human melanoma cell line-BioVector NTCC典型培养物保藏中心

The NTCC™ SK-MEL-23 cell line is a human melanoma cell line used extensively in cancer research. It was established from a metastatic lymph node of a 67-year-old female patient with malignant melanoma.

Key Characteristics

• Origin: The cell line was developed by Memorial Sloan Kettering Cancer Center (MSKCC). It's one of a large series of melanoma cell lines derived by researchers to study the disease.

• Melanin Production: SK-MEL-23 cells are notable for being highly pigmented, meaning they contain a significant amount of melanin. This feature makes them a valuable model for studying the effects of melanin and melanogenesis (the process of melanin synthesis) on various treatments and cellular processes.

• Genetic Profile: The cell line has a homozygous deletion in the PTEN gene. This is a significant characteristic, as PTEN is a well-known tumor suppressor gene. The loss of PTEN function is common in many cancers, including melanoma, and leads to the activation of pro-survival pathways.

• Morphology and Growth: SK-MEL-23 cells are adherent and grow as a monolayer.

Research Applications

Due to its specific characteristics, the SK-MEL-23 cell line is a critical tool for several areas of research:

• Melanoma Biology: It serves as a model for understanding the biology of malignant melanoma, particularly the role of melanin in the disease's progression and response to therapy.

• Drug and Therapy Screening: The cell line is used to test the efficacy of new drugs and therapies, including targeted agents and immunotherapies. Its response to a wide range of compounds is well-documented, making it a reliable model for preclinical studies.

• Photobiology and Laser Research: Its high melanin content makes it an ideal model for studying the effects of light, particularly lasers, on pigmented cells. Researchers have used it to investigate sub-lethal damage from laser exposure and its effect on melanin content and related genes like tyrosinase.

NTCC™ SK-MEL-23 细胞系是一种广泛用于癌症研究的人类黑色素瘤细胞系。它建立于一名67岁女性恶性黑色素瘤患者的转移性淋巴结。

主要特点

• 来源: 该细胞系由纪念斯隆-凯特琳癌症中心（MSKCC）开发。它是一系列为研究该疾病而分离的黑色素瘤细胞系中的一个。

• 黑色素生成: SK-MEL-23 细胞的一个显著特点是其高度色素化，意味着它们含有大量的黑色素。这一特性使其成为研究黑色素及其合成过程（黑素生成）对各种治疗和细胞过程影响的宝贵模型。

• 遗传学特征: 该细胞系在 PTEN 基因中存在纯合性缺失。这是一个重要特征，因为 PTEN 是一个著名的抑癌基因。PTEN 功能的丧失在包括黑色素瘤在内的许多癌症中很常见，并导致促生存通路的激活。

• 形态与生长: SK-MEL-23 细胞是贴壁生长的，形成单层。

研究应用

由于其独特的特性，SK-MEL-23 细胞系是几个研究领域的关键工具：

• 黑色素瘤生物学: 它作为研究恶性黑色素瘤生物学的模型，特别是研究黑色素在该疾病进展和治疗反应中的作用。

• 药物和疗法筛选: 该细胞系用于测试新药物和疗法（包括靶向药物和免疫疗法）的有效性。它对各种化合物的反应有详细记录，使其成为临床前研究的可靠模型。

• 光生物学和激光研究: 其高黑色素含量使其成为研究光（特别是激光）对色素细胞影响的理想模型。研究人员已用它来研究激光照射造成的亚致死性损伤及其对黑色素含量和相关基因（如酪氨酸酶）的影响。