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TOPFlash载体质粒图谱序列抗性价格报价Biovector NTCC Inc.现货

  • 价  格:¥3920
  • 货  号:BiovectorTOPFlash
  • 产  地:北京
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TOPFlash 载体

出品公司:Millipore
质粒类型:信号通路报告载体
克隆方法:多克隆位点,限制性内切酶
载体抗性:Ampicillin (氨苄青霉素)

订购信息载体质粒图谱


TOPFlash载体图谱



TOPFlash载体特征

载体简介




The Wnt/Wg family encodes secreted glycoproteins implicated in cell growth regulation, cell fate determination, organogenesis and oncogenesis. Inferred from genetic analysis of wingless (wg) signaling in Drosophila, in mammalian cells, Wnts signal through the Frizzled family of receptors, to Dishevelled. Dishevelled down regulates glycogen synthase kinase-3 (GSK-3 ) activity. This results in the stabilization and accumulation of cytosolic -catenin, a GSK-3 substrate, which when phosphorylated by GSK-3, is targeted for ubiquitin-mediated proteolysis. -catenin then translocates to the nucleus, where in complexes with members of the Tcf/LEF family of transcription regulators, activates transcription of Tcf-responsive genes. This Tcf-reporter plasmid, along with FOPFLASH (Cat. # 21-169) enables quantitation of Wnt/Wg signaling in cells transfected with these constructs.



FOPFlash 载体

基本信息

质粒类型:信号通路报告载体
克隆方法:多克隆位点,限制性内切酶
产品编号产品名称规格价格
Biovector101593FOPFlash

5ug质粒

¥1920.00

Transfection grade T cell factor (Tcf) reporter plasmid containing three copies of the Tcf binding site (mutated) upstream of the Thymidine Kinase (TK) minimal promoter and Luciferase open reading frame. This plasmid serves as a negative control to TOPFLASH (Catalog # 21-170) which contains wild type Tcf binding sites.

Background

Transfection grade T cell factor (Tcf) reporter plasmid containing three copies of the Tcf binding site (mutated) upstream of the Thymidine Kinase (TK) minimal promoter and Luciferase open reading frame. This plasmid serves as a negative control to TOPFLASH (Catalog # 21-170) which contains wild type Tcf binding sites.



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